Target Information

Target General Infomation
Target ID
T67942
Former ID
TTDR00871
Target Name
Cystathionine gamma-synthase
Gene Name
metB
Synonyms
CGS; O-succinylhomoserine (Thiol)-lyase; metB
Target Type
Research
Function
Catalyzes the formation of L-cystathionine from O- succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma- replacement reaction. In the absence of thiol, catalyzes gamma- elimination to form 2-oxobutanoate, succinate and ammonia.
BioChemical Class
Alkyl aryl transferase
UniProt ID
P00935
EC Number
EC 2.5.1.48
Sequence
MTRKQATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRAHDYSRRGNPTRDVVQRA
LAELEGGAGAVLTNTGMSAIHLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVL
FVDQGDEQALRAALAEKPKLVLVESPSNPLLRVVDIAKICHLAREVGAVSVVDNTFLSPA
LQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTGGAFDSYL
LLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAML
SFELDGDEQTLRRFLGGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLL
RISTGIEDGEDLIADLENGFRAANKG
Inhibitor 5-carboxymethylthio-3-(3'-chlorophenyl)-1,2,4-oxadiazol Drug Info [535242]
N'-Pyridoxyl-Lysine-5'-Monophosphate Drug Info [551393]
References
Ref 535242Crystal structures of cystathionine gamma-synthase inhibitor complexes rationalize the increased affinity of a novel inhibitor. J Mol Biol. 2001 Aug 24;311(4):789-801.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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