Target Information
Target General Infomation | |||||
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Target ID |
T54065
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Former ID |
TTDR01019
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Target Name |
3-phosphoshikimate1-carboxyvinyltransferase
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Gene Name |
aroA
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Synonyms |
5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS; aroA
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Target Type |
Research
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Disease | Malaria [ICD10: B54] | ||||
Function |
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
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BioChemical Class |
Alkyl aryl transferase
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UniProt ID | |||||
EC Number |
EC 2.5.1.19
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Sequence |
MESLTLQPIARVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTAL
GVSYTLSADRTRCEIIGNGGPLHAEGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEPR MKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSVSSQFLTALLMTA PLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVE GDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYISCTRGE LNAIDMDMNHIPDAAMTIATAALFAKGTTTLRNIYNWRVKETDRLFAMATELRKVGAEVE EGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDTPVTILDPKCTAKTFPDYFEQL ARISQAA |
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Structure |
1RF4; 1RF5; 1RF6; 1EPS; 1G6S; 1G6T; 1MI4; 1P88; 1P89; 1Q0I; 1Q0J; 1Q36; 1X8R; 1X8T; 2AA9; 2AAY; 2PQ9; 2QFQ; 2QFS; 2QFT; 2QFU; 3FJX; 3FJZ; 3FK0; 3FK1
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References |
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