Target Information
Target General Infomation | |||||
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Target ID |
T35445
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Former ID |
TTDR00819
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Target Name |
Mothers against decapentaplegic homolog 3
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Gene Name |
SMAD3
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Synonyms |
HMAD-3; HSMAD3; JV15-2; MMad3; Mad3; Mothers against DPP homolog 3; SMAD 3; Smad3; TGF-beta response effector Smad3; SMAD3
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Target Type |
Successful
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Disease | Ocular disease [ICD10: H00-H59] | ||||
Function |
Transcriptional modulator activated by tgf-beta (transforming growth factor) and activin type 1 receptor kinase. Smad3 is a receptor-regulated smad (r-smad). In mouse required for establishemnt of the mucosal immune response.
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Target Validation |
T35445
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UniProt ID | |||||
Sequence |
MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNV
NTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEV CVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSNIPETP PPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYEL NQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIG GEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGF EAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIR CSSVS |
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Drugs and Mode of Action | |||||
References |
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