Target Information
Target General Infomation | |||||
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Target ID |
T34563
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Former ID |
TTDR00089
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Target Name |
D-amino acid aminotransferase
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Gene Name |
dat
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Synonyms |
D-alanine aminotransferase; D-amino acid transaminase; D-aspartate aminotransferase; DAAT; dat
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Target Type |
Research
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Function |
Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine. The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine andan alpha- keto acid in the first half-reaction. The second half-reaction is the reverse of the first, transferring the amino group from the pyridoxamine to a second alpha-keto acid to form the product D- amino acid via a ping-pong mechanism. This is an important process in the formation of D-alanine and D-glutamate, which are essential bacterial cell wall components (By similarity).
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BioChemical Class |
Transferases of nitrogenous groups
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UniProt ID | |||||
EC Number |
EC 2.6.1.21
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Sequence |
MTKVFINGEFIDQNEAKVSYEDRGYVFGDGIYEYIRAYDGKLFTVTEHFERFIRSASEIQ
LDLGYTVEELIDVVRELLKVNNIQNGGIYIQATRGVAPRNHSFPTPEVKPVIMAFAKSYD RPYDDLENGINAATVEDIRWLRCDIKSLNLLGNVLAKEYAVKYNAGEAIQHRGETVTEGA SSNVYAIKDGAIYTHPVNNYILNGITRKVIKWISEDEDIPFKEETFTVEFLKNADEVIVS STSAEVTPVVKIDGEQVGDGKVGPVTRQLQEGFNKYIESRSS |
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References |
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