Target Information

Target General Infomation
Target ID
T34337
Former ID
TTDR01143
Target Name
Undecaprenyl pyrophosphate synthetase
Gene Name
ispU
Synonyms
Di-trans-poly-cis-decaprenylcistransferase; UDS; UPP synthase; UPP synthetase; Undecaprenyl diphosphate synthase; Undecaprenyl diphosphate synthase; ispU
Target Type
Research
Function
Generates ditrans,octacis-undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP) and farnesyl diphosphate (FPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.
BioChemical Class
Alkyl aryl transferase
UniProt ID
P60472
EC Number
EC 2.5.1.31
Sequence
MMLSATQPLSEKLPAHGCRHVAIIMDGNGRWAKKQGKIRAFGHKAGAKSVRRAVSFAANN
GIEALTLYAFSSENWNRPAQEVSALMELFVWALDSEVKSLHRHNVRLRIIGDTSRFNSRL
QERIRKSEALTAGNTGLTLNIAANYGGRWDIVQGVRQLAEKVQQGNLQPDQIDEEMLNQH
VCMHELAPVDLVIRTGGEHRISNFLLWQIAYAELYFTDVLWPDFDEQDFEGALNAFANRE
RRFGGTEPGDETA
Inhibitor E-pentenylbutanedioic acid 32 Drug Info [535900]
ISOPENTENYL PYROPHOSPHATE Drug Info [551374]
References
Ref 535900Synthesis and biological activity of isopentenyl diphosphate analogues. Bioorg Med Chem. 2004 Feb 15;12(4):763-70.
Ref 551374The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.

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