Target Information
Target General Infomation | |||||
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Target ID |
T31956
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Former ID |
TTDR00531
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Target Name |
Glutamyl aminopeptidase
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Gene Name |
ENPEP
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Synonyms |
APA; Aminopeptidase A; Differentiation antigen gp160; EAP; ENPEP
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Target Type |
Clinical Trial
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Disease | Hypertension [ICD9: 401; ICD10: I10-I16] | ||||
Function |
Appears to have a role in the catabolicpathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells.
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BioChemical Class |
Peptidase
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Target Validation |
T31956
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UniProt ID | |||||
EC Number |
EC 3.4.11.7
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Sequence |
MNFAEREGSKRYCIQTKHVAILCAVVVGVGLIVGLAVGLTRSCDSSGDGGPGTAPAPSHL
PSSTASPSGPPAQDQDICPASEDESGQWKNFRLPDFVNPVHYDLHVKPLLEEDTYTGTVS ISINLSAPTRYLWLHLRETRITRLPELKRPSGDQVQVRRCFEYKKQEYVVVEAEEELTPS SGDGLYLLTMEFAGWLNGSLVGFYRTTYTENGQVKSIVATDHEPTDARKSFPCFDEPNKK ATYTISITHPKEYGALSNMPVAKEESVDDKWTRTTFEKSVPMSTYLVCFAVHQFDSVKRI SNSGKPLTIYVQPEQKHTAEYAANITKSVFDYFEEYFAMNYSLPKLDKIAIPDFGTGAME NWGLITYRETNLLYDPKESASSNQQRVATVVAHELVHQWFGNIVTMDWWEDLWLNEGFAS FFEFLGVNHAETDWQMRDQMLLEDVLPVQEDDSLMSSHPIIVTVTTPDEITSVFDGISYS KGSSILRMLEDWIKPENFQKGCQMYLEKYQFKNAKTSDFWAALEEASRLPVKEVMDTWTR QMGYPVLNVNGVKNITQKRFLLDPRANPSQPPSDLGYTWNIPVKWTEDNITSSVLFNRSE KEGITLNSSNPSGNAFLKINPDHIGFYRVNYEVATWDSIATALSLNHKTFSSADRASLID DAFALARAQLLDYKVALNLTKYLKREENFLPWQRVISAVTYIISMFEDDKELYPMIEEYF QGQVKPIADSLGWNDAGDHVTKLLRSSVLGFACKMGDREALNNASSLFEQWLNGTVSLPV NLRLLVYRYGMQNSGNEISWNYTLEQYQKTSLAQEKEKLLYGLASVKNVTLLSRYLDLLK DTNLIKTQDVFTVIRYISYNSYGKNMAWNWIQLNWDYLVNRYTLNNRNLGRIVTIAEPFN TELQLWQMESFFAKYPQAGAGEKPREQVLETVKNNIEWLKQHRNTIREWFFNLLESG |
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Drugs and Mode of Action | |||||
Pathways | |||||
KEGG Pathway | Renin-angiotensin system | ||||
NetPath Pathway | IL2 Signaling Pathway | ||||
Reactome | Metabolism of Angiotensinogen to Angiotensins | ||||
WikiPathways | Metabolism of Angiotensinogen to Angiotensins | ||||
References | |||||
Ref 525655 | Investigation of subsite preferences in aminopeptidase A (EC 3.4.11.7) led to the design of the first highly potent and selective inhibitors of this enzyme. J Med Chem. 1999 Dec 16;42(25):5197-211. | ||||
Ref 533380 | J Med Chem. 1988 Sep;31(9):1825-31.Retro-inverso concept applied to the complete inhibitors of enkephalin-degrading enzymes. |
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