Target Information

Target General Infomation
Target ID
T30653
Former ID
TTDS00133
Target Name
Lyso-PAF: acetyl-CoA acetyltransferase
Synonyms
Acetyl-CoA: 1-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase; LysoPAF acetyltransferase
Target Type
Successful
Disease Obesity [ICD9: 278; ICD10: E66]
Target Validation
T30653
Drugs and Mode of Action
Drug(s) Quercetin Drug Info Approved Obesity [535696], [540783]
Inhibitor Luteolin Drug Info [538004]
Quercetin Drug Info [535696], [538004]
References
Ref 535696Modulation by flavonoids of PAF and related phospholipids in endothelial cells during oxidative stress. J Lipid Res. 2003 Feb;44(2):380-7. Epub 2002 Nov 4.
Ref 540783(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5346).
Ref 535696Modulation by flavonoids of PAF and related phospholipids in endothelial cells during oxidative stress. J Lipid Res. 2003 Feb;44(2):380-7. Epub 2002 Nov 4.
Ref 538004Inhibition of lysoPAF acetyltransferase activity by flavonoids. Inflamm Res. 1996 Nov;45(11):546-9.

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