Target Information
Target General Infomation | |||||
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Target ID |
T30040
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Former ID |
TTDR00926
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Target Name |
Vascular endothelial growth factor B
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Gene Name |
VEGFB
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Synonyms |
VEGF-B; VEGF-related factor; VRF; VEGFB
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Target Type |
Successful
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Disease | Metastatic colorectal cancer [ICD9: 153, 154; ICD10: C18-C21] | ||||
Function |
Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.
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BioChemical Class |
PDGF VEGF growth factor
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UniProt ID | |||||
Sequence |
MSPLLRRLLLAALLQLAPAQAPVSQPDAPGHQRKVVSWIDVYTRATCQPREVVVPLTVEL
MGTVAKQLVPSCVTVQRCGGCCPDDGLECVPTGQHQVRMQILMIRYPSSQLGEMSLEEHS QCECRPKKKDSAVKPDRAATPHHRPQPRSVPGWDSAPGAPSPADITHPTPAPGPSAHAAP STTSALTPGPAAAAADAAASSVAKGGA |
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Drugs and Mode of Action | |||||
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
TEP | EXP Info | ||||
Pathways | |||||
KEGG Pathway | Ras signaling pathway | ||||
Rap1 signaling pathway | |||||
Cytokine-cytokine receptor interaction | |||||
PI3K-Akt signaling pathway | |||||
Focal adhesion | |||||
Pathways in cancer | |||||
NetPath Pathway | TSH Signaling Pathway | ||||
Pathway Interaction Database | VEGFR1 specific signals | ||||
Reactome | Platelet degranulation | ||||
VEGF ligand-receptor interactions | |||||
VEGF binds to VEGFR leading to receptor dimerization | |||||
WikiPathways | Focal Adhesion | ||||
Signaling by VEGF | |||||
Heart Development | |||||
References |
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