Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T25889
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| Former ID |
TTDR00979
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| Target Name |
Adenylate cyclase
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| Synonyms |
ATP pyrophosphate-lyase; Adenylyl cyclase
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| Target Type |
Discontinued
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| Disease | Cardiac failure [ICD10: I50] | ||||
| Cancer [ICD9: 140-229; ICD10: C00-C96] | |||||
| Function |
Catalyzes the formation of the second messenger cAMP from ATP. Its transcript is probably degraded by endoribonuclease LS (rnlA), decreasing cAMP levels and the negative regulator Crp- cAMP, which then induces its own transcription again.
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| BioChemical Class |
Phosphorus-oxygen lyases
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| Target Validation |
T25889
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| EC Number |
EC 4.6.1.1
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| Drugs and Mode of Action | |||||
| Drug(s) | Ad5-AC6 | Drug Info | Terminated | Cardiac failure | [1] |
| Inhibitor | 2,3,17BETA-TRIHYDROXY-1,3,5(10)-ESTRATRIENE | Drug Info | [2] | ||
| 2,5-didesoxy-3-ATP | Drug Info | [3] | |||
| 2-hydroxy-17beta-estradiol | Drug Info | [3] | |||
| Adenosine-5'-Rp-Alpha-Thio-Triphosphate | Drug Info | [4] | |||
| Alpha,Beta-Methyleneadenosine-5'-Triphosphate | Drug Info | [5] | |||
| Cyclic Adenosine Monophosphate | Drug Info | [5] | |||
| DEOXYADENOSINE | Drug Info | [6] | |||
| N6-CYCLOPENTYLADENOSINE | Drug Info | [7] | |||
| NSC-270718 | Drug Info | [3] | |||
| NSC-88915 | Drug Info | [3] | |||
| Modulator | Ad5-AC6 | Drug Info | [8] | ||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013170) | ||||
| REF 2 | The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. | ||||
| REF 3 | J Med Chem. 2008 Aug 14;51(15):4456-64. Epub 2008 Jul 17.Structure-based development of novel adenylyl cyclase inhibitors. | ||||
| REF 4 | DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-4. Nucleic Acids Res. 2011 January | ||||
| REF 5 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | ||||
| REF 6 | J Med Chem. 2004 Feb 26;47(5):1207-13.Synthesis of 2',5'-dideoxy-2-fluoroadenosine and 2',5'-dideoxy-2,5'-difluoroadenosine: potent P-site inhibitors of adenylyl cyclase. | ||||
| REF 7 | J Med Chem. 1991 Dec;34(12):3388-90.Activity of N6-substituted 2-chloroadenosines at A1 and A2 adenosine receptors. | ||||
| REF 8 | Unanticipated Signaling Events Associated with Cardiac Adenylyl Cyclase Gene Transfer. J Mol Cell Cardiol. 2011 May; 50(5): 751-758. | ||||
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