Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T25164
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| Former ID |
TTDR00747
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| Target Name |
Flavohemoglobin
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| Gene Name |
hmp
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| Synonyms |
Dihydropteridine reductase; Ferrisiderophore reductase B; HMP; Hemoglobin-like protein; NO oxygenase; NOD; Nitric oxide dioxygenase; hmp
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| Target Type |
Research
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| Function |
Various electron acceptors arealso reduced by HMP in vitro, including dihydropterine, ferrisiderophores, ferric citrate, cytochrome c, nitrite, S-nitrosoglutathione, and alkylhydroperoxides. However, it is unknown if these reactions are of any biological significance in vivo.
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| BioChemical Class |
Oxidoreductases acting on paired donors
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| UniProt ID | |||||
| EC Number |
EC 1.6.99.7
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| Sequence |
MLDAQTIATVKATIPLLVETGPKLTAHFYDRMFTHNPELKEIFNMSNQRNGDQREALFNA
IAAYASNIENLPALLPAVEKIAQKHTSFQIKPEQYNIVGEHLLATLDEMFSPGQEVLDAW GKAYGVLANVFINREAEIYNENASKAGGWEGTRDFRIVAKTPRSALITSFELEPVDGGAV AEYRPGQYLGVWLKPEGFPHQEIRQYSLTRKPDGKGYRIAVKREEGGQVSNWLHNHANVG DVVKLVAPAGDFFMAVADDTPVTLISAGVGQTPMLAMLDTLAKAGHTAQVNWFHAAENGD VHAFADEVKELGQSLPRFTAHTWYRQPSEADRAKGQFDSEGLMDLSKLEGAFSDPTMQFY LCGPVGFMQFTAKQLVDLGVKQENIHYECFGPHKVL |
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| Inhibitor | 2-(N-Morpholino)-Ethanesulfonic Acid | Drug Info | [1] | ||
| Flavin-Adenine Dinucleotide | Drug Info | [1] | |||
| Heme | Drug Info | [2] | |||
| Nicotinamide-Adenine-Dinucleotide | Drug Info | [1] | |||
| References | |||||
| REF 1 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | ||||
| REF 2 | The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. | ||||
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