Target Information

Target General Infomation
Target ID
T23688
Former ID
TTDR00022
Target Name
3-Deoxy-D-manno-octulosonate 8-phosphate synthase
Gene Name
kdsA
Synonyms
2-dehydro-3-deoxyphosphooctonate aldolase; 3-Deoxy-d-manno-2-octulosonate-8-phosphate synthase; 3-deoxy-D-manno-octulosonic acid 8-phosphate synthetase; KDO-8-phosphate synthetase; KDO8-P synthase; KDO8P synthase; KDO8PS; KDOP synthase; KDOPS; Phospho-2-dehydro-3-deoxyoctonate aldolase; kdsA
Target Type
Research
Function
Synthesis of KDO 8-P which is required for lipid A maturation and cellular growth.
BioChemical Class
Alkyl aryl transferase
UniProt ID
P0A715
EC Number
EC 2.5.1.55
Sequence
MKQKVVSIGDINVANDLPFVLFGGMNVLESRDLAMRICEHYVTVTQKLGIPYVFKASFDK
ANRSSIHSYRGPGLEEGMKIFQELKQTFGVKIITDVHEPSQAQPVADVVDVIQLPAFLAR
QTDLVEAMAKTGAVINVKKPQFVSPGQMGNIVDKFKEGGNEKVILCDRGANFGYDNLVVD
MLGFSIMKKVSGNSPVIFDVTHALQCRDPFGAASGGRRAQVAELARAGMAVGLAGLFIEA
HPDPEHAKCDGPSALPLAKLEPFLKQMKAIDDLVKGFEELDTSK
Inhibitor 1-Deoxy-Ribofuranose-5'-Phosphate Drug Info [551393]
2-(Phosphonooxy)Butanoic Acid Drug Info [551391]
2-Phosphoglyceric Acid Drug Info [551393]
3-Fluoro-2-(Phosphonooxy)Propanoic Acid Drug Info [551393]
Arabinose-5-Phosphate Drug Info [551393]
Erythose-4-Phosphate Drug Info [551393]
Phosphoenolpyruvate Drug Info [551393]
Ribose-5-Phosphate Drug Info [551393]
References
Ref 551391DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-4. Nucleic Acids Res. 2011 January
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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