Target Information

Target General Infomation
Target ID
T21396
Target Name
Bacterial 30S ribosome subunit
Target Type
Successful
Disease Advanced gum disease; Chronic periodontitis [ICD9: 523.4, 523.5; ICD10: K05.3, K05.4]
Bacterial infections [ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104; ICD10: A00-B99]
Diabetic foot ulcer [ICD9: 707; ICD10: L88-L89]
Drugs and Mode of Action
Drug(s) Doxycycline Drug Info Approved Advanced gum disease; Chronic periodontitis [536773], [541599]
Gentamicin Drug Info Approved Bacterial infections [536773], [539556]
Doxycycline Drug Info Phase 2 Diabetic foot ulcer [522450]
Modulator Doxycycline Drug Info [556264]
Gentamicin Drug Info [556264]
References
Ref 522450ClinicalTrials.gov (NCT00764361) Safety Study of Topical Doxycycline Gel for Adult Diabetic Lower Extremity Ulcers. U.S. National Institutes of Health.
Ref 536773How many modes of action should an antibiotic have? Curr Opin Pharmacol. 2008 Oct;8(5):564-73. Epub 2008 Jul 30.
Ref 539556(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2427).
Ref 541599(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6464).
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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