Target Information

Target General Infomation
Target ID
T03573
Former ID
TTDNC00464
Target Name
CD32b
Gene Name
FCGR2B
Synonyms
CD32; CDw32; FcRIIb; Fcgamma RIIb; FcgammaRIIb; IgG Fc receptor IIb; Low affinity immunoglobulin gamma Fc region receptor IIb; FCGR2B
Target Type
Clinical Trial
Disease Autoimmune diabetes [ICD10: E08-E13]
Rheumatoid arthritis [ICD9: 710-719, 714; ICD10: M05-M06]
Function
Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B- cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.
UniProt ID
P31994
Sequence
MGILSFLPVLATESDWADCKSPQPWGHMLLWTAVLFLAPVAGTPAAPPKAVLKLEPQWIN
VLQEDSVTLTCRGTHSPESDSIQWFHNGNLIPTHTQPSYRFKANNNDSGEYTCQTGQTSL
SDPVHLTVLSEWLVLQTPHLEFQEGETIVLRCHSWKDKPLVKVTFFQNGKSKKFSRSDPN
FSIPQANHSHSGDYHCTGNIGYTLYSSKPVTITVQAPSSSPMGIIVAVVTGIAVAAIVAA
VVALIYCRKKRISALPGYPECREMGETLPEKPANPTNPDEADKVGAENTITYSLLMHPDA
LEEPDDQNRI
Drugs and Mode of Action
Drug(s) Xmab 5871 Drug Info Phase 2 Autoimmune diabetes [549317]
Xmab5871 Drug Info Phase 1/2 Rheumatoid arthritis [889425]
Modulator Xmab 5871 Drug Info [531971]
Xmab5871 Drug Info [889442]
Pathways
KEGG Pathway Phagosome
Osteoclast differentiation
B cell receptor signaling pathway
Fc gamma R-mediated phagocytosis
Staphylococcus aureus infection
Tuberculosis
Measles
NetPath Pathway Leptin Signaling Pathway
Pathway Interaction Database Fc-epsilon receptor I signaling in mast cells
BCR signaling pathway
Reactome Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
WikiPathways Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
References
Ref 549317Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800035125)
Ref 889425ClinicalTrials.gov (NCT02867098) XmAb5871 Bioavailability Study
Ref 531971CD19 as an attractive target for antibody-based therapy. MAbs. 2012 Sep-Oct;4(5):571-7.
Ref 889442Bispecific antibodies rise again. Nat Rev Drug Discov. 2014 Nov;13(11):799-801. doi: 10.1038/nrd4478.

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