Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T01280
|
||||
| Former ID |
TTDI03051
|
||||
| Target Name |
beta-site APP-cleaving enzyme 2
|
||||
| Gene Name |
BACE2
|
||||
| Synonyms |
BACE2
|
||||
| Target Type |
Clinical Trial
|
||||
| Disease | Focal segmental glomerulosclerosis [ICD10: N00-N08] | ||||
| UniProt ID | |||||
| Sequence |
MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGL
ALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAG TPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATI FESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVA GSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKA IVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISI YLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFD RAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCG AILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK |
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| Drugs and Mode of Action | |||||
| Drug(s) | example 98 (WO2011020806) | Drug Info | Clinical trial | Focal segmental glomerulosclerosis | [1] |
| Inhibitor | 2ewy | Drug Info | [2] | ||
| compound J | Drug Info | [3] | |||
| example 2 (WO2013004676) | Drug Info | [4] | |||
| example 20 (WO2010128058) | Drug Info | [5] | |||
| example 41 (WO2012028563) | Drug Info | [5] | |||
| example 92 (WO2012095521) | Drug Info | [5] | |||
| example 98 (WO2011020806) | Drug Info | [6] | |||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6540). | ||||
| REF 2 | Crystal structure of human BACE2 in complex with a hydroxyethylamine transition-state inhibitor. J Mol Biol. 2006 Jan 13;355(2):249-61. Epub 2005 Nov 8. | ||||
| REF 3 | Bace2 is a beta cell-enriched protease that regulates pancreatic beta cell function and mass. Cell Metab. 2011 Sep 7;14(3):365-77. | ||||
| REF 4 | Cyclopropyl-Fused 1,3-Thiazepines as BACE1 and BACE2 Inhibitors. ACS Med Chem Lett. 2013 Mar 15;4(4):379-80. | ||||
| REF 5 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2331). | ||||
| REF 6 | BACE2 as a new diabetes target: a patent review (2010 - 2012). Expert Opin Ther Pat. 2013 May;23(5):649-63. | ||||
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