Target Information

Target General Infomation
Target ID
T00902
Former ID
TTDI02363
Target Name
Neurotrophin-4 ligand
Gene Name
NTF4
Synonyms
NT4; NT5; Neurotrophin4; Neurotrophin5; Neutrophic factor 4; NTF4
Target Type
Discontinued
Disease Central nervous system disease [ICD10: G00-G99]
Function
Target-derived survival factor for peripheral sensory sympathetic neurons.
BioChemical Class
NGF-beta family
UniProt ID
P34130
Sequence
MLPLPSCSLPILLLFLLPSVPIESQPPPSTLPPFLAPEWDLLSPRVVLSRGAPAGPPLLF
LLEAGAFRESAGAPANRSRRGVSETAPASRRGELAVCDAVSGWVTDRRTAVDLRGREVEV
LGEVPAAGGSPLRQYFFETRCKADNAEEGGPGAGGGGCRGVDRRHWVSECKAKQSYVRAL
TADAQGRVGWRWIRIDTACVCTLLSRTGRA
Drugs and Mode of Action
Drug(s) ReN-1826 Drug Info Terminated Central nervous system disease [547600]
Inhibitor ReN-1826 Drug Info [528418]
Pathways
KEGG Pathway MAPK signaling pathway
Neurotrophin signaling pathway
NetPath Pathway TNFalpha Signaling Pathway
Pathway Interaction Database SHP2 signaling
p75(NTR)-mediated signaling
Neurotrophic factor-mediated Trk receptor signaling
WikiPathways MAPK Signaling Pathway
Differentiation Pathway
References
Ref 547600Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017722)
Ref 528418Pulmonary distribution, regulation, and functional role of Trk receptors in a murine model of asthma. J Allergy Clin Immunol. 2006 Sep;118(3):597-605. Epub 2006 Jul 3.

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