Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T65291
|
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| Former ID |
TTDS00053
|
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| Target Name |
Aldehyde dehydrogenase
|
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| Gene Name |
ALDH3A2
|
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| Synonyms |
ALDH3A2
|
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| Target Type |
Successful
|
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| Disease | Alcohol use disorders [ICD9: 303; ICD10: F10.2] | ||||
| Epilepsy [ICD10: G40] | |||||
| BioChemical Class |
Oxidoreductases acting on aldehyde or oxo group of donors
|
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| Target Validation |
T65291
|
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| UniProt ID | |||||
| EC Number |
EC 1.2.1.8
|
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| Sequence |
MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE
VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDH IFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQT CIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKI AFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLA LYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFS HQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKRFNKEKLGLLLLTFLGIVAAVLV KAEYY |
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| Drugs and Mode of Action | |||||
| Drug(s) | Disulfiram | Drug Info | Approved | Alcohol use disorders | [1], [2] |
| NPS 1776 | Drug Info | Discontinued in Phase 2 | Epilepsy | [3] | |
| Inhibitor | Aloe-emodin | Drug Info | [4] | ||
| Disulfiram | Drug Info | [5] | |||
| NSC-527035 | Drug Info | [6] | |||
| S-methyl 4-methyl-4-morpholinopent-2-ynethioate | Drug Info | [7] | |||
| Modulator | NPS 1776 | Drug Info | [8] | ||
| Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
| TEP | EXP Info | ||||
| References | |||||
| REF 1 | Choosing the right medication for the treatment of alcoholism. Curr Psychiatry Rep. 2006 Oct;8(5):383-8. | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7168). | ||||
| REF 3 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010984) | ||||
| REF 4 | Elgonica-Dimers A and B, Two Potent Alcohol Metabolism Inhibitory Constituents of Aloe arborescens J. Nat. Prod. 60(11):1180-1182 (1997). | ||||
| REF 5 | Pharmacological treatment of alcohol dependence: target symptoms and target mechanisms. Pharmacol Ther. 2006 Sep;111(3):855-76. Epub 2006 Mar 20. | ||||
| REF 6 | J Med Chem. 2010 Apr 8;53(7):2757-65.Exploring the structural requirements for inhibition of the ubiquitin E3 ligase breast cancer associated protein 2 (BCA2) as a treatment for breast cancer. | ||||
| REF 7 | Eur J Med Chem. 2008 May;43(5):906-16. Epub 2007 Jul 6.Aldehyde dehydrogenase inhibitors: alpha,beta-acetylenic N-substituted aminothiolesters are reversible growth inhibitors of normal epithelial but irreversible apoptogens for cancer epithelial cells from human prostate in culture. | ||||
| REF 8 | Diverse Mechanisms of Antiepileptic Drugs in the Development Pipeline. Epilepsy Res. 2006 June; 69(3): 273-294. | ||||
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