Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T65116
|
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| Former ID |
TTDR01229
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| Target Name |
5'-Nucleotidase
|
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| Gene Name |
NT5E
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| Synonyms |
5'-NT; CD73 antigen; Ecto-5'-nucleotidase; NT5E
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| Target Type |
Research
|
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| Function |
Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities.
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| BioChemical Class |
Phosphoric monoester hydrolases
|
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| Target Validation |
T65116
|
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| UniProt ID | |||||
| EC Number |
EC 3.1.3.5
|
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| Sequence |
MCPRAARAPATLLLALGAVLWPAAGAWELTILHTNDVHSRLEQTSEDSSKCVNASRCMGG
VARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEF DNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKE TPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVV GGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNV ISSHGNPILLNSSIPEDPSIKADINKWRIKLDNYSTQELGKTIVYLDGSSQSCRFRECNM GNLICDAMINNNLRHTDEMFWNHVSMCILNGGGIRSPIDERNNGTITWENLAAVLPFGGT FDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCR VPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYP AVEGRIKFSTGSHCHGSFSLIFLSLWAVIFVLYQ |
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| Inhibitor | Acid blue 25 | Drug Info | [1] | ||
| alphabeta-methyleneADP | Drug Info | [2] | |||
| PSB-0952 | Drug Info | [1] | |||
| PSB-0963 | Drug Info | [1] | |||
| RB 2 | Drug Info | [1] | |||
| Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
| TEP | EXP Info | ||||
| Pathways | |||||
| BioCyc Pathway | Purine nucleotides degradation | ||||
| Urate biosynthesis/inosine 5' | |||||
| -phosphate degradation | |||||
| Adenosine nucleotides degradation | |||||
| KEGG Pathway | Purine metabolism | ||||
| Pyrimidine metabolism | |||||
| Nicotinate and nicotinamide metabolism | |||||
| Metabolic pathways | |||||
| PANTHER Pathway | Purine metabolism | ||||
| Pyrimidine Metabolism | |||||
| Pathway Interaction Database | HIF-1-alpha transcription factor network | ||||
| Reactome | Purine catabolism | ||||
| WikiPathways | Differentiation Pathway | ||||
| miR-targeted genes in muscle cell - TarBase | |||||
| miR-targeted genes in lymphocytes - TarBase | |||||
| miR-targeted genes in epithelium - TarBase | |||||
| Metabolism of nucleotides | |||||
| References | |||||
| REF 1 | J Med Chem. 2010 Mar 11;53(5):2076-86.Development of potent and selective inhibitors of ecto-5'-nucleotidase based on an anthraquinone scaffold. | ||||
| REF 2 | 5'-Nucleotidase from smooth muscle of small intestine and from brain. Inhibition of nucleotides. Biochemistry. 1975 Jun 3;14(11):2362-6. | ||||
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