Target expression details
Target General Information | |||||
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Target ID | T97071 | ||||
Target Name | Glutamate carboxypeptidase II | ||||
Synonyms | FGCP; Folate hydrolase 1; Folylpoly-gamma-glutamate carboxypeptidase; MGCP; Membrane glutamate carboxypeptidase; N-acetylated-alpha-linked acidic dipeptidase I; NAALADase I; PSM; PSMA; Prostate-specific membrane antigen; Pteroylpoly-gamma-glutamate carboxypeptidase; FOLH1 | ||||
Target Type | Successful | ||||
Gene Name | FOLH1 | ||||
Biochemical Class | Peptidase | ||||
UniProt ID | FOLH1_HUMAN | ||||
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
Disease | Prostate cancer | ||||
Example drug | Capromab | Approved | [538379], [541934], [551871], [1572592] | ||
Tissue | Prostate | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 2.08 Z-score: 2.21 P-value: 1.40E-09 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
Reference | |||||
Ref 538379 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (BLA) 103608. | ||||
Ref 541934 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6878). |
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