Target expression details
Target General Information | |||||
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Target ID | T97035 | ||||
Target Name | Tyrosinase | ||||
Synonyms | LB24-AB; Monophenol monooxygenase; SK29-AB; Tumor rejection antigen AB; Tyrosinase; TYR | ||||
Target Type | Successful | ||||
Gene Name | TYR | ||||
Biochemical Class | Tyrosinase | ||||
UniProt ID | TYRO_HUMAN | ||||
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
Disease | Vitiligo | ||||
Example drug | Monobenzone | Approved | [538404], [541911], [1572592] | ||
Tissue | Skin | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.70 Z-score: -1.43 P-value: 5.23E-04 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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Disease | Melanoma | ||||
Example drug | Melanoma vaccine | Phase 3 | [521514], [1572592] | ||
Tissue | Skin | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 2.54 Z-score: 1.15 P-value: 6.68E-04 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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Disease | Rheumatoid arthritis | ||||
Tissue | Synovial tissue | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.14 Z-score: -0.76 P-value: 5.99E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
Reference | |||||
Ref 538404 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 008173. | ||||
Ref 541911 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6830). |
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