Target General Information
Target ID T97035
Target Name Tyrosinase
Synonyms LB24-AB; Monophenol monooxygenase; SK29-AB; Tumor rejection antigen AB; Tyrosinase; TYR
Target Type Successful
Gene Name TYR
Biochemical Class Tyrosinase
UniProt ID TYRO_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Vitiligo
Example drug Monobenzone Approved [538404], [541911], [1572592]
Tissue Skin
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -0.70
Z-score: -1.43
P-value: 5.23E-04
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Disease Melanoma
Example drug Melanoma vaccine Phase 3 [521514], [1572592]
Tissue Skin
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 2.54
Z-score: 1.15
P-value: 6.68E-04
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Disease Rheumatoid arthritis
Tissue Synovial tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -0.14
Z-score: -0.76
P-value: 5.99E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Reference
Ref
Ref 538404FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 008173.
Ref 541911(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6830).
Ref 521514ClinicalTrials.gov (NCT00036816) Vaccine Therapy in Treating Patients With Melanoma of the Eye. U.S. National Institutes of Health.
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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