TTD | Expression Details

Target General Information
Target ID	T94479
Target Name	Ribosomal protein S6 kinase
Synonyms	P70-S6K; S6K; RPS6KB1
Target Type	Clinical Trial
Gene Name	RPS6KA1
Biochemical Class	Kinase
UniProt ID	KS6A1_HUMAN\|\|KS6A2_HUMAN\|\|KS6A3_HUMAN\|\|KS6A4_HUMAN\|\|KS6A5_HUMAN\|\|KS6A6_HUMAN\|\|KS6B1_HUMAN\|\|KS6B2_HUMAN\|\|KS6C1_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Ulcerative colitis
Example drug	PF-4708671			Clinical trial	[531100], [1572592]
Tissue	Colon mucosal tissue
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section	Fold-change: 0.03 Z-score: 0.07 P-value: 4.83E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of the persons with other diseases not directly affecting the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of the persons with other diseases not directly affecting the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 531100	Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). Biochem J. 2010 Oct 15;431(2):245-55.
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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