Target expression details

Target General Information
Target ID T92076
Target Name Extracellular calcium-sensing receptor
Synonyms CaSR; Parathyroid Cell calcium-sensing receptor; Parathyroid calcium receptor; Parathyroid cell calciumreceptor; CASR
Target Type Successful
Gene Name CASR {ECO:0000312|HGNC:HGNC:1514}||Synonyms=GPRC2A, PCAR1 {ECO:0000303|PubMed:8698326}
Biochemical Class GPCR glutamate
UniProt ID CASR_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Myelodysplastic syndromes
Example drug AMG 416 Phase 3 [548996], [1572592]
Tissue Bone marrow
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -0.03
Z-score: -0.19
P-value: 5.81E-02
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section Fold-change: -0.01
Z-score: -0.08
P-value: 9.29E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
Download target gene expression data of the patients in the disease section of the tissue
Download target gene expression data of the patients in the normal section of the tissue adjacent to the disease section
Download target gene expression data in the tissue of healthy individual
Disease Osteoporosis
Example drug MK-5442 Phase 2 [522761], [1572592]
Tissue Bone marrow
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 0.23
Z-score: 4.10
P-value: 4.50E-02
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Download target gene expression data of the patients in the disease section of the tissue
Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 548996Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031284)
Ref 522761ClinicalTrials.gov (NCT00960934) A Dose-Ranging Study of MK-5442 in Postmenopausal Women With Osteoporosis (MK-5442-001). U.S. National Institutes of Health.
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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