Target General Information
Target ID T82577
Target Name Angiotensin-converting enzyme
Synonyms CD143 antigen; Dipeptidyl carboxypeptidase I; Kininase II; ACE
Target Type Successful
Gene Name ACE
Biochemical Class Glycosylases
UniProt ID ACE_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Depression
Example drug Ceranapril Discontinued in Phase 2 [544627], [1572592]
Tissue Pre-frontal cortex
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -0.01
Z-score: -0.06
P-value: 2.62E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Reference
Ref 544627Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000355)
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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