Target General Information
Target ID T79232
Target Name Vasopressin V1a receptor
Synonyms AVPR V1a; Antidiuretic hormone receptor 1a; V1a vasopressin receptor; V1aR; Vascular/hepatic-type arginine vasopressin receptor; AVPR1A
Target Type Successful
Gene Name AVPR1A
Biochemical Class GPCR rhodopsin
UniProt ID V1AR_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Septic shock
Example drug Selepressin Phase 2 [523936], [1572592]
Tissue Whole blood
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -0.12
Z-score: -0.34
P-value: 8.89E-04
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Reference
Ref 523936ClinicalTrials.gov (NCT01612676) Investigating FE 202158 as Potential Primary Treatment in Patients With Early Septic Shock. U.S. National Institutes of Health.
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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