TTD | Expression Details

Target General Information
Target ID	T78464
Target Name	Prostaglandin G/H synthase COX-2
Synonyms	COX-2; Cyclooxygenase -2; Cyclooxygenase 2; Cyclooxygenase-2; Heme-protein prostaglandin G/H synthase; PGH synthase 2; PGHS-2; PHS II; Prostaglandin H2 synthase 2; Prostaglandin-endoperoxide synthase 2; PTGS2
Target Type	Successful
Gene Name	PTGS2
Biochemical Class	Oxidoreductases acting on paired donors
UniProt ID	PGH2_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Osteoarthritis
Example drug	Celecoxib	Approved	[1], [2], [3]
Tissue	Synovial tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 1.67 Z-score: 0.74 P-value: 3.32E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Rheumatoid arthritis
Example drug	Flurbiprofen	Approved	[4], [5], [3]
Tissue	Synovial tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 1.36 Z-score: 2.49 P-value: 9.92E-06
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Alzheimer's disease
Example drug	DOCOSAHEXAENOIC ACID	Phase 3	[6], [3]
Tissue	Entorhinal cortex
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.29 Z-score: -0.34 P-value: 7.93E-04
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Asthma
Example drug	Darbufelone	Phase 2/3	[7], [3]
Tissue	Nasal and bronchial airway
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.86 Z-score: 0.64 P-value: 1.50E-04
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Type 2 diabetes
Example drug	CRx-401	Discontinued in Phase 2	[8], [3]
Tissue	Liver tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 1.68E-03 Z-score: 0.03 P-value: 2.08E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Endometriosis
Example drug	NS398	Terminated	[9], [3]
Tissue	Endometrium tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.90 Z-score: -0.50 P-value: 1.40E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Colon cancer
Tissue	Colon tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 1.57 Z-score: 1.70 P-value: 1.64E-44
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section	Fold-change: 1.04 Z-score: 0.75 P-value: 2.06E-10
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data of the patients in the normal section of the tissue adjacent to the disease section Download target gene expression data in the tissue of healthy individual
Disease	Rectal cancer
Tissue	Rectal colon tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 1.68 Z-score: 3.86 P-value: 2.03E-07
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section	Fold-change: 1.91 Z-score: 2.92 P-value: 3.56E-05
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data of the patients in the normal section of the tissue adjacent to the disease section Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
REF 1	New drugs in development for the treatment of endometriosis. Expert Opin Investig Drugs. 2008 Aug;17(8):1187-202.
REF 2	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2892).
REF 3	NCBI GEO: archive for functional genomics data sets--update.
REF 4	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4194).
REF 5	FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 074358.
REF 6	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1051).
REF 7	Novel dual cyclooxygenase and lipoxygenase inhibitors targeting hyaluronan-CD44v6 pathway and inducing cytotoxicity in colon cancer cells. Bioorg Med Chem. 2013 May 1;21(9):2551-9.
REF 8	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018957)
REF 9	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002344)

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Target expression details

Prof. Feng ZHU

Prof. Yuzong CHEN