Target expression details
Target General Information | |||||
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Target ID | T73992 | ||||
Target Name | Beta-secretase | ||||
Synonyms | BACE1; ASP2; Aspartyl protease 2; BACE; Beta-site AbetaPP-cleaving enzyme; Beta-site amyloid precursor protein cleaving enzyme; Memapsin-2; Membrane-associated aspartic protease 2; Transmembrane aspartic protease | ||||
Target Type | Clinical Trial | ||||
Gene Name | BACE1 | ||||
Biochemical Class | Peptidase | ||||
UniProt ID | BACE1_HUMAN||BACE2_HUMAN | ||||
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
Disease | Rheumatoid arthritis | ||||
Example drug | AZ-4217 | Clinical trial | [532395], [1572592] | ||
Tissue | Synovial tissue | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 1.03 Z-score: 2.84 P-value: 6.98E-04 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
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