Target General Information
Target ID T73215
Target Name B lymphocyte surface antigen B1
Synonyms B-lymphocyte surface antigen B1; Bp35; CD20; Leu-16; MS4A1
Target Type Successful
Gene Name MS4A1
Biochemical Class CD20 ca(2+) channel
UniProt ID CD20_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Multiple sclerosis
Example drug Ocrelizumab Approved [889446], [1572592]
Tissue Spinal cord
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section Fold-change: 0.15
Z-score: 1.27
P-value: 4.83E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Disease Rheumatoid arthritis
Example drug SBI-087 Phase 2 [522841], [1572592]
Tissue Synovial tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 0.25
Z-score: 0.56
P-value: 4.00E-02
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Reference
Ref 522841ClinicalTrials.gov (NCT01008852) Study Evaluating The Efficacy And Safety Of SBI-087 In Seropositive Subjects With Active Rheumatoid Arthritis. U.S. National Institutes of Health.
Ref 889446Drugs@FDA (Edaravone)
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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