Target expression details
| Target General Information | |||||
|---|---|---|---|---|---|
| Target ID | T67102 | ||||
| Target Name | Cathepsin D | ||||
| Synonyms | CD; CTSD | ||||
| Target Type | Clinical Trial | ||||
| Gene Name | CTSD | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | CATD_HUMAN | ||||
| Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
| Disease | Multiple sclerosis | ||||
| Example drug | compound 1 | Clinical trial | [1], [2], [3] | ||
| Tissue | Spinal cord | ||||
| Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section | Fold-change: -0.26 Z-score: -0.58 P-value: 4.83E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
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| Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
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| Reference | |||||
| REF 1 | Synthesis and structure activity relationships of novel small molecule cathepsin D inhibitors. Bioorg Med Chem Lett. 1999 Sep 6;9(17):2531-6. | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6541). | ||||
| REF 3 | NCBI GEO: archive for functional genomics data sets--update. | ||||
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