Target expression details
Target General Information | |||||
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Target ID | T63934 | ||||
Target Name | Interferon alpha-2 | ||||
Synonyms | IFNalpha2; Interferon alpha2; Interferon alphaA; LeIF A; IFNA2 | ||||
Target Type | Successful | ||||
Gene Name | IFNA2 | ||||
Biochemical Class | Cytokine: interferon | ||||
UniProt ID | IFNA2_HUMAN | ||||
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
Disease | Melanoma | ||||
Example drug | Interferon Alfa-2b | Approved | [551871], [1572592] | ||
Tissue | Skin | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.16 Z-score: -0.42 P-value: 3.08E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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Disease | Bladder cancer | ||||
Example drug | Instiladrin | Phase 2 | [524056], [1572592] | ||
Tissue | Bladder tissue | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 0.35 Z-score: 2.05 P-value: 9.31E-04 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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Disease | Rectal cancer | ||||
Example drug | Novaferon | Phase 2 | [525215], [1572592] | ||
Tissue | Rectal colon tissue | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.17 Z-score: -0.73 P-value: 3.04E-01 |
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Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section | Fold-change: 0.04 Z-score: 0.19 P-value: 9.85E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
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Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
Reference | |||||
Ref 524056 | ClinicalTrials.gov (NCT01687244) Intravesical Administration of rAd-IFN/Syn3 in Patients With BCG-Refractory or Relapsed Bladder Cancer. U.S. National Institutes of Health. | ||||
Ref 525215 | ClinicalTrials.gov (NCT02455596) Recombinant Anti-tumor and Anti-virus Protein for Injection to Treat Advanced Neuroendocrine Tumors. |
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