Target expression details
| Target General Information | |||||
|---|---|---|---|---|---|
| Target ID | T56923 | ||||
| Target Name | C-X-C chemokine receptor type 2 | ||||
| Synonyms | CDw128b; CXCR-2; GRO/MGSA receptor; IL-8 receptor type 2; IL-8R B; Interleukin-8 receptor B; CXCR2 | ||||
| Target Type | Successful | ||||
| Gene Name | CXCR2 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | CXCR2_HUMAN | ||||
| Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
| Disease | Chronic obstructive pulmonary disease | ||||
| Example drug | SB-656933 | Phase 2 | [1], [2], [3] | ||
| Tissue | Lung tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.23 Z-score: -0.21 P-value: 8.82E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Chronic obstructive pulmonary disease | ||||
| Example drug | SB-656933 | Phase 2 | [1], [2], [3] | ||
| Tissue | Small airway epithelium | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 0.21 Z-score: 0.19 P-value: 1.34E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
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| Reference | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8499). | ||||
| REF 2 | Clinical pipeline report, company report or official report of GlaxoSmithKline. | ||||
| REF 3 | NCBI GEO: archive for functional genomics data sets--update. | ||||
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