Target expression details
| Target General Information | |||||
|---|---|---|---|---|---|
| Target ID | T55959 | ||||
| Target Name | Dopamine transporter | ||||
| Synonyms | DA transporter; DAT; Dopamine transporter; SLC6A3 | ||||
| Target Type | Successful | ||||
| Gene Name | SLC6A3 | ||||
| Biochemical Class | Neurotransmitter:sodium symporter | ||||
| UniProt ID | SC6A3_HUMAN | ||||
| Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
| Disease | Parkinson's disease | ||||
| Example drug | Ioflupane i-123 | Approved | [1], [2] | ||
| Tissue | Substantia nigra tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -3.08 Z-score: -1.99 P-value: 1.08E-03 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Depression | ||||
| Example drug | GSK-1360707 | Phase 1 | [3], [2] | ||
| Tissue | Pre-frontal cortex | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 4.04E-03 Z-score: 0.02 P-value: 4.17E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
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| Reference | |||||
| REF 1 | 2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4. | ||||
| REF 2 | NCBI GEO: archive for functional genomics data sets--update. | ||||
| REF 3 | ClinicalTrials.gov (NCT01153802) An Open Label Positron Emission Tomography Study in Healthy Male Subjects to Investigate Brain DAT and SERT Occupancy,Pharmacokinetics and Safety of Single Oral Dosesof GSK1360707, Using 11C- PE2I and 11C-DASB as PET Ligands. U.S. National Institutes of Health. | ||||
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