Target expression details
| Target General Information | |||||
|---|---|---|---|---|---|
| Target ID | T47107 | ||||
| Target Name | Protein kinase C gamma | ||||
| Synonyms | PKC-gamma; PKCG; PRKCG | ||||
| Target Type | Successful | ||||
| Gene Name | PRKCG | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | KPCG_HUMAN | ||||
| Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
| Disease | Acute myelocytic leukemia | ||||
| Example drug | Midostaurin | Approved | [889446], [1572592] | ||
| Tissue | Bone marrow | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 0.06 Z-score: 0.30 P-value: 9.42E-04 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Breast cancer | ||||
| Example drug | Midostaurin | Phase 2 | [889446], [1572592] | ||
| Tissue | Breast tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.07 Z-score: -0.35 P-value: 5.25E-10 |
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| Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section | Fold-change: -0.02 Z-score: -0.07 P-value: 3.54E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
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| Disease | Colon cancer | ||||
| Example drug | Midostaurin | Phase 2 | [889446], [1572592] | ||
| Tissue | Colon tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.02 Z-score: -0.10 P-value: 2.49E-01 |
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| Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section | Fold-change: -0.09 Z-score: -0.38 P-value: 6.32E-05 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
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| Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
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