Target expression details
Target General Information | |||||
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Target ID | T38529 | ||||
Target Name | Prostaglandin E2 receptor EP2 | ||||
Synonyms | EP2 receptor; PGE receptor, EP2 subtype; Prostanoid EP2 receptor; PTGER2 | ||||
Target Type | Successful | ||||
Gene Name | PTGER2 | ||||
Biochemical Class | GPCR rhodopsin | ||||
UniProt ID | PE2R2_HUMAN | ||||
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
Disease | Endometriosis | ||||
Example drug | PF-4418948 | Phase 1 | [522833], [541135], [1572592] | ||
Tissue | Endometrium tissue | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 1.15 Z-score: 1.37 P-value: 2.77E-06 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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Disease | Osteoporosis | ||||
Tissue | Bone marrow | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -1.29 Z-score: -1.07 P-value: 1.73E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
Reference | |||||
Ref 541135 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5817). |
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