Target expression details
Target General Information | |||||
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Target ID | T37510 | ||||
Target Name | Coagulation Factor Va | ||||
Synonyms | Factor Va; F5 | ||||
Target Type | Successful | ||||
Gene Name | F5 | ||||
Biochemical Class | Multicopper oxidase family | ||||
UniProt ID | FA5_HUMAN | ||||
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
Disease | Sepsis | ||||
Example drug | Drotrecogin alfa | Approved | [536361], [541868], [551871], [1572592] | ||
Tissue | Whole blood | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 1.93 Z-score: 2.54 P-value: 2.14E-37 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
Reference | |||||
Ref 541868 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6788). | ||||
Ref 536361 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. |
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