Target General Information
Target ID T31391
Target Name Dipeptidyl peptidase IV
Synonyms ADABP; ADCP2; Adenosine deaminase complexing protein 2; Adenosine deaminase complexing protein-2; CD26; DPP 4; DPP IV; DPP-IV; Dipeptidyl peptidase 4; Dipeptidyl peptidase 4 soluble form; Dipeptidyl peptidase IV; T-cell activation antigen CD26; TP103; Tcell activation antigen CD26; DPP4
Target Type Successful
Gene Name DPP4
Biochemical Class Peptidase
UniProt ID DPP4_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Type 2 diabetes
Example drug Dapagliflozin Propanediol; Saxagliptin Hydrochloride Approved [889446], [1572592]
Tissue Liver tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -0.27
Z-score: -1.85
P-value: 9.54E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Disease Psoriasis
Example drug IP10 C8 Phase 2 [1572592]
Tissue Skin
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 8.70E-03
Z-score: 1.20E-02
P-value: 5.40E-02
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section Fold-change: 0.68
Z-score: 0.81
P-value: 6.42E-08
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Reference
Ref 889446Drugs@FDA (Edaravone)
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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