Target expression details
| Target General Information | |||||
|---|---|---|---|---|---|
| Target ID | T24587 | ||||
| Target Name | O-6-methylguanine-DNA-alkyltransferase | ||||
| Synonyms | 6-O-methylguanine-DNA methyltransferase; Human O(6)-alkylguanine-DNA alkyltransferase; O-6-methylguanine-DNA-alkyltransferase; MGMT | ||||
| Target Type | Clinical Trial | ||||
| Gene Name | MGMT | ||||
| Biochemical Class | Methyltransferase superfamily | ||||
| UniProt ID | MGMT_HUMAN | ||||
| Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
| Disease | Sarcoma | ||||
| Example drug | O6-Benzylguanine alkylade | Phase 3 | [527774], [529958], [1572592] | ||
| Tissue | Muscle tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.31 Z-score: -0.83 P-value: 1.21E-12 |
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| Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section | Fold-change: 0.11 Z-score: 0.58 P-value: 2.53E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
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| Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
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| Reference | |||||
| Ref 527774 | Phase I trial of temozolomide plus O6-benzylguanine for patients with recurrent or progressive malignant glioma. J Clin Oncol. 2005 Oct 1;23(28):7178-87. | ||||
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