Target expression details
Target General Information | |||||
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Target ID | T11309 | ||||
Target Name | C-C motif chemokine 2 | ||||
Synonyms | HC11; MCAF; MCP-1; MCP1; Monocyte Chemoattractant Protein 1; Monocyte chemoattractant protein-1; Monocyte chemotactic and activating factor; Monocyte chemotactic protein 1; Monocyte secretory protein JE; SCYA2; Small-inducible cytokine A2; CCL2 | ||||
Target Type | Clinical Trial | ||||
Gene Name | CCL2 | ||||
Biochemical Class | Cytokine: CC chemokine | ||||
UniProt ID | CCL2_HUMAN | ||||
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
Disease | Chronic obstructive pulmonary disease | ||||
Example drug | RS-504393 | Preclinical | [536223], [542757], [1572592] | ||
Tissue | Lung tissue | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 0.79 Z-score: 0.56 P-value: 3.77E-02 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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Disease | Chronic obstructive pulmonary disease | ||||
Example drug | RS-504393 | Preclinical | [536223], [542757], [1572592] | ||
Tissue | Small airway epithelium | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 1.32 Z-score: 1.24 P-value: 9.17E-07 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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Disease | Rheumatoid arthritis | ||||
Example drug | MCP-1 | Preclinical | [536223], [1572592] | ||
Tissue | Synovial tissue | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 3.57 Z-score: 4.42 P-value: 3.76E-06 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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Disease | Asthma | ||||
Example drug | ABN-912 | Discontinued in Phase 1 | [547919], [1572592] | ||
Tissue | Nasal and bronchial airway | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 0.07 Z-score: 0.10 P-value: 1.98E-02 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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Disease | Idiopathic pulmonary fibrosis | ||||
Tissue | Lung tissue | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.66 Z-score: -0.49 P-value: 2.07E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
Reference | |||||
Ref 547919 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020409) | ||||
Ref 542757 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 781). |
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