Target expression details
Target General Information | |||||
---|---|---|---|---|---|
Target ID | T09960 | ||||
Target Name | C-C chemokine receptor type 5 | ||||
Synonyms | C-C CKR-5; CC-CKR-5; CCR-5; CD195 antigen; CHEMR13; Chemokine receptor CCR5; HIV-1 fusion co-receptor; HIV-1 fusion coreceptor; CCR5 | ||||
Target Type | Successful | ||||
Gene Name | CCR5 | ||||
Biochemical Class | GPCR rhodopsin | ||||
UniProt ID | CCR5_HUMAN | ||||
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
Disease | Chronic obstructive pulmonary disease | ||||
Example drug | Maraviroc | Phase 3 | [529282], [536223], [542947], [1572592] | ||
Tissue | Lung tissue | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 0.03 Z-score: 0.05 P-value: 5.10E-01 |
||||
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
|
|||||
Disease | Chronic obstructive pulmonary disease | ||||
Example drug | Maraviroc | Phase 3 | [529282], [536223], [542947], [1572592] | ||
Tissue | Small airway epithelium | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 1.04E-02 Z-score: 0.02 P-value: 5.43E-01 |
||||
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
|
|||||
Disease | Rheumatoid arthritis | ||||
Example drug | AZD8566 | Discontinued in Phase 1 | [548691], [1572592] | ||
Tissue | Synovial tissue | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.08 Z-score: -0.11 P-value: 9.30E-01 |
||||
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
|
|||||
Reference | |||||
Ref 548691 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027710) | ||||
Ref 542947 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 806). |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.