Target expression details
| Target General Information | |||||
|---|---|---|---|---|---|
| Target ID | T01318 | ||||
| Target Name | Dihydroorotate dehydrogenase | ||||
| Synonyms | DHOD; DHODH; DHODase; DHOdehase; Dihydroorotate dehydrogenase ; Dihydroorotate oxidase; Mitochondrially bound dihydroorotate-ubiqui oxidoreductase; PFF0160c | ||||
| Target Type | Successful | ||||
| Gene Name | DHODH | ||||
| Biochemical Class | Oxidoreductases acting on CH-CH group of donors | ||||
| UniProt ID | PYRD_HUMAN | ||||
| Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
| Disease | Multiple sclerosis | ||||
| Example drug | Leflunomide | Approved | [1], [2], [3], [4] | ||
| Tissue | Spinal cord | ||||
| Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section | Fold-change: 0.18 Z-score: 0.63 P-value: 3.25E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
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| Disease | Rheumatoid arthritis | ||||
| Example drug | Leflunomide | Approved | [1], [2], [3], [4] | ||
| Tissue | Synovial tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.61 Z-score: -2.46 P-value: 9.02E-04 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
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| Reference | |||||
| REF 1 | Nat Rev Drug Discov. 2013 Feb;12(2):87-90. | ||||
| REF 2 | New drugs in development for the treatment of endometriosis. Expert Opin Investig Drugs. 2008 Aug;17(8):1187-202. | ||||
| REF 3 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6825). | ||||
| REF 4 | NCBI GEO: archive for functional genomics data sets--update. | ||||
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