Target Validation Information
Target ID T22976
Target Name Deoxyribonucleoside phosphotransferase
Target Type
Research
Drug Potency against Target 1-[6-(triphenylmethoxy)hexyl]thymine Drug Info IC50 = 17000 nM [528583]
1-[5-(triphenylmethoxy)pentyl]thymine Drug Info IC50 = 15000 nM [528583]
1-[(Z)-4-(triphenylmethoxy)-2-butenyl]thymine Drug Info IC50 = 3300 nM [528583]
References
Ref 528583J Med Chem. 2006 Dec 28;49(26):7766-73.N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors.
Ref 528583J Med Chem. 2006 Dec 28;49(26):7766-73.N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors.
Ref 528583J Med Chem. 2006 Dec 28;49(26):7766-73.N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors.

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