| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T99402 | ||||
| Target Name | Metabotropic glutamate receptor 4 | ||||
| Target Type | Research |
||||
| Drug Potency against Target | L-1-amino-4-phosphonobutanoic acid | Drug Info | Ki = 160 nM | [528723] | |
| (2S,1'R,2'S)-2-(2'-phosphonocyclopropyl)glycine | Drug Info | Ki = 7400 nM | [528723] | ||
| GLUTAMATE | Drug Info | Ki = 3400 nM | [528723] | ||
| References | |||||
| Ref 528723 | Bioorg Med Chem. 2007 May 1;15(9):3161-70. Epub 2007 Feb 22.Synthesis and preliminary pharmacological evaluation of the four stereoisomers of (2S)-2-(2'-phosphono-3'-phenylcyclopropyl)glycine, the first class of 3'-substituted trans C1'-2'-2-(2'-phosphonocyclopropyl)glycines. | ||||
| Ref 528723 | Bioorg Med Chem. 2007 May 1;15(9):3161-70. Epub 2007 Feb 22.Synthesis and preliminary pharmacological evaluation of the four stereoisomers of (2S)-2-(2'-phosphono-3'-phenylcyclopropyl)glycine, the first class of 3'-substituted trans C1'-2'-2-(2'-phosphonocyclopropyl)glycines. | ||||
| Ref 528723 | Bioorg Med Chem. 2007 May 1;15(9):3161-70. Epub 2007 Feb 22.Synthesis and preliminary pharmacological evaluation of the four stereoisomers of (2S)-2-(2'-phosphono-3'-phenylcyclopropyl)glycine, the first class of 3'-substituted trans C1'-2'-2-(2'-phosphonocyclopropyl)glycines. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.