| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T19923 | ||||
| Target Name | mRNA of Bcl-x | ||||
| Target Type | Discontinued |
||||
| Drug Potency against Target | QEDIIRNIARHLAQVGDSMDR | Drug Info | Ki = 7 nM | [528469] | |
| TW-37 | Drug Info | Ki = 1110 nM | [530763] | ||
| PURPUROGALLIN | Drug Info | IC50 = 2200 nM | [526790] | ||
| 4,5-dibenzylbenzene-1,2-diol | Drug Info | IC50 = 8500 nM | [530890] | ||
| References | |||||
| Ref 528469 | J Med Chem. 2006 Oct 19;49(21):6139-42.Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins. | ||||
| Ref 530763 | J Med Chem. 2010 Mar 25;53(6):2577-88.Fragment-based deconstruction of Bcl-xL inhibitors. | ||||
| Ref 526790 | J Med Chem. 2003 Sep 25;46(20):4259-64.Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins. | ||||
| Ref 530890 | J Med Chem. 2010 May 27;53(10):3899-906.Vaccinia virus virulence factor N1L is a novel promising target for antiviral therapeutic intervention. | ||||
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