Target Validation Information
Target ID T81015
Target Name Orotidine 5'-phosphate decarboxylase
Target Type
Research
Drug Potency against Target Xanthosine-5'-monophosphate disodium salt Drug Info Ki = 400 nM [529249]
6-amino-uridine monophosphate Drug Info Ki = 840 nM [528351]
6-aza-uridine monophosphate Drug Info Ki = 12400 nM [528351]
References
Ref 529249J Med Chem. 2008 Feb 14;51(3):432-8. Epub 2008 Jan 9.Structural diversity and plasticity associated with nucleotides targeting orotidine monophosphate decarboxylase.
Ref 528351J Med Chem. 2006 Aug 10;49(16):4937-45.Design of inhibitors of orotidine monophosphate decarboxylase using bioisosteric replacement and determination of inhibition kinetics.
Ref 528351J Med Chem. 2006 Aug 10;49(16):4937-45.Design of inhibitors of orotidine monophosphate decarboxylase using bioisosteric replacement and determination of inhibition kinetics.

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