Target Validation Information
Target ID T06671
Target Name Interleukin-18
Target Type
Clinical Trial
Drug Potency against Target Iboctadekin + rituximab Drug Info Ki = 300000 nM [552569]
Action against Disease Model IL-18BP Levels of IL-18 were found to correlate with ser uM ferritin values and disease severity in adult-onset Still's disease (ASD). Western blot analysis revealed that ser uM samplesfrom patients with active ASD contained an 18-kd polypeptide of IL-18, corresponding in size to the mature form. Accordingly, the samples were able to induce IFNgamma secretion from KG-1 cells, whichwas largely abolished by neutralizing anti-IL-18 antibody. [552249] Drug Info
The Effect of Target Knockout, Knockdown or Genetic Variations Gene deletion resulted in Eosinophilia and Airway hyperresponsiveness increase compared to wild type [552249]
References
Ref 552249Levels of interleukin-18 and its binding inhibitors in the blood circulation of patients with adult-onset Still's disease. Arthritis Rheum. 2001 Mar;44(3):550-60.
Ref 552569Recent developments of structure based beta-secretase inhibitors for Alzheimer's disease. Curr Top Med Chem. 2005;5(16):1609-22.

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