| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T53764 | ||||
| Target Name | Seprase | ||||
| Target Type | Clinical Trial |
||||
| Drug Potency against Target | PF-00734200 | Drug Info | IC50 = 10300 nM | [530008] | |
| N-alkyl Gly-boro-Pro derivative | Drug Info | IC50 = 4.6 nM | [527678] | ||
| References | |||||
| Ref 530008 | Bioorg Med Chem Lett. 2009 Apr 1;19(7):1991-5. Epub 2009 Feb 13.(3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone: a potent, selective, orally active dipeptidyl peptidase IV inhibitor. | ||||
| Ref 527678 | Bioorg Med Chem Lett. 2005 Oct 1;15(19):4239-42.Synthesis and structure-activity relationship of N-alkyl Gly-boro-Pro inhibitors of DPP4, FAP, and DPP7. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.