Target Validation Information | |||||
---|---|---|---|---|---|
Target ID | T75596 | ||||
Target Name | Methionine aminopeptidase 2 | ||||
Target Type | Clinical Trial |
||||
Drug Potency against Target | 5-chloro-2-(pyridin-2-yl)-1H-benzo[d]imidazole | Drug Info | IC50 = 18100 nM | ||
2-(pyridin-2-yl)-1H-imidazo[4,5-c]pyridine | Drug Info | IC50 = 8000 nM | |||
2-(pyridin-2-yl)-1H-benzo[d]imidazole | Drug Info | IC50 = 13300 nM | |||
5-methyl-2-(pyridin-2-yl)-1H-benzo[d]imidazole | Drug Info | IC50 = 7700 nM | |||
5-p-Tolyl-1H-[1,2,3]triazole | Drug Info | IC50 = 10 nM | [527712] | ||
3-anilino-5-benzylthio-1,2,4-triazole | Drug Info | Ki = 0.5 nM | [528951] | ||
2-(thiazol-4-yl)-1H-benzo[d]imidazol-5-amine | Drug Info | IC50 = 10100 nM | |||
2-(pyridin-2-yl)-1H-benzo[d]imidazol-5-amine | Drug Info | IC50 = 9300 nM | |||
OXYQUINOLINE | Drug Info | IC50 = 5600 nM | |||
2-(4-fluorophenylsulfonamido)-1-naphthoic acid | Drug Info | IC50 = 15 nM | [528149] | ||
2-(phenylsulfonamido)-5-propylbenzoic acid | Drug Info | IC50 = 1100 nM | [528149] | ||
5-ethyl-2-(phenylsulfonamido)benzoic acid | Drug Info | IC50 = 90 nM | [528149] | ||
2-(phenylsulfonamido)-1-naphthoic acid | Drug Info | IC50 = 19 nM | [528149] | ||
5-methyl-2-(phenylsulfonamido)benzoic acid | Drug Info | IC50 = 1400 nM | [528266] | ||
5-bromo-2-(4-chlorophenylsulfonamido)benzoic acid | Drug Info | IC50 = 9100 nM | [528149] | ||
3,5-dimethyl-2-(phenylsulfonamido)benzoic acid | Drug Info | IC50 = 350 nM | [528149] | ||
5-butyl-2-(phenylsulfonamido)benzoic acid | Drug Info | IC50 = 10000 nM | [528149] | ||
References | |||||
Ref 527712 | J Med Chem. 2005 Sep 8;48(18):5644-7.4-Aryl-1,2,3-triazole: a novel template for a reversible methionine aminopeptidase 2 inhibitor, optimized to inhibit angiogenesis in vivo. | ||||
Ref 528951 | J Med Chem. 2007 Aug 9;50(16):3777-85. Epub 2007 Jul 18.Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore. | ||||
Ref 528149 | Bioorg Med Chem Lett. 2006 Jul 1;16(13):3574-7. Epub 2006 May 2.Development of sulfonamide compounds as potent methionine aminopeptidase type II inhibitors with antiproliferative properties. | ||||
Ref 528149 | Bioorg Med Chem Lett. 2006 Jul 1;16(13):3574-7. Epub 2006 May 2.Development of sulfonamide compounds as potent methionine aminopeptidase type II inhibitors with antiproliferative properties. | ||||
Ref 528149 | Bioorg Med Chem Lett. 2006 Jul 1;16(13):3574-7. Epub 2006 May 2.Development of sulfonamide compounds as potent methionine aminopeptidase type II inhibitors with antiproliferative properties. | ||||
Ref 528149 | Bioorg Med Chem Lett. 2006 Jul 1;16(13):3574-7. Epub 2006 May 2.Development of sulfonamide compounds as potent methionine aminopeptidase type II inhibitors with antiproliferative properties. | ||||
Ref 528266 | J Med Chem. 2006 Jun 29;49(13):3832-49.Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: a structural basis for the reduction of albumin binding. | ||||
Ref 528149 | Bioorg Med Chem Lett. 2006 Jul 1;16(13):3574-7. Epub 2006 May 2.Development of sulfonamide compounds as potent methionine aminopeptidase type II inhibitors with antiproliferative properties. | ||||
Ref 528149 | Bioorg Med Chem Lett. 2006 Jul 1;16(13):3574-7. Epub 2006 May 2.Development of sulfonamide compounds as potent methionine aminopeptidase type II inhibitors with antiproliferative properties. | ||||
Ref 528149 | Bioorg Med Chem Lett. 2006 Jul 1;16(13):3574-7. Epub 2006 May 2.Development of sulfonamide compounds as potent methionine aminopeptidase type II inhibitors with antiproliferative properties. |
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