Target Validation Information
Target ID T27944
Target Name Neuropeptide Y receptor type 4
Target Type
Discontinued
Drug Potency against Target H-[Trp-Arg-Nva-Arg-Tyr]3-NH2 Drug Info Ki = 3.9 nM [528136]
Adp[-Trp-Arg-Nva-Arg-Tyr-NH2]2 Drug Info Ki = 4.2 nM [528136]
Sub[-Trp-Arg-Nva-Arg-Tyr-NH2]2 Drug Info Ki = 4.1 nM [528136]
[Cys-Trp-Arg-Nva-Arg-Tyr-NH2]2 Drug Info Ki = 30 nM [528136]
Pim[-Trp-Arg-Nva-Arg-Tyr-NH2]2 Drug Info Ki = 4.3 nM [528136]
H-[Trp-Arg-Nva-Arg-Tyr]2-NH2 Drug Info Ki = 5.3 nM [528136]
The Effect of Target Knockout, Knockdown or Genetic Variations Slower heart rate and lower blood pressure [528136]
References
Ref 528136J Med Chem. 2006 Apr 20;49(8):2661-5.Neuropeptide Y (NPY) Y4 receptor selective agonists based on NPY(32-36): development of an anorectic Y4 receptor selective agonist with picomolar affinity.
Ref 528136J Med Chem. 2006 Apr 20;49(8):2661-5.Neuropeptide Y (NPY) Y4 receptor selective agonists based on NPY(32-36): development of an anorectic Y4 receptor selective agonist with picomolar affinity.
Ref 528136J Med Chem. 2006 Apr 20;49(8):2661-5.Neuropeptide Y (NPY) Y4 receptor selective agonists based on NPY(32-36): development of an anorectic Y4 receptor selective agonist with picomolar affinity.
Ref 528136J Med Chem. 2006 Apr 20;49(8):2661-5.Neuropeptide Y (NPY) Y4 receptor selective agonists based on NPY(32-36): development of an anorectic Y4 receptor selective agonist with picomolar affinity.
Ref 528136J Med Chem. 2006 Apr 20;49(8):2661-5.Neuropeptide Y (NPY) Y4 receptor selective agonists based on NPY(32-36): development of an anorectic Y4 receptor selective agonist with picomolar affinity.
Ref 528136J Med Chem. 2006 Apr 20;49(8):2661-5.Neuropeptide Y (NPY) Y4 receptor selective agonists based on NPY(32-36): development of an anorectic Y4 receptor selective agonist with picomolar affinity.

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