| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T81100 | ||||
| Target Name | mRNA of sodium-glucosetransporter-2 | ||||
| Target Type | Clinical Trial |
||||
| Drug Potency against Target | SERGLIFLOZIN A | Drug Info | IC50 = 6.25 nM | [530750] | |
| Sophoraflavanone G | Drug Info | IC50 = 4100 nM | [528742] | ||
| KURARINONE | Drug Info | IC50 = 1700 nM | [528742] | ||
| O-spiroketal glucoside | Drug Info | IC50 = 6.5 nM | [530988] | ||
| References | |||||
| Ref 530750 | Bioorg Med Chem. 2010 Mar 15;18(6):2178-94. Epub 2010 Feb 4.Novel C-aryl glucoside SGLT2 inhibitors as potential antidiabetic agents: 1,3,4-Thiadiazolylmethylphenyl glucoside congeners. | ||||
| Ref 528742 | Bioorg Med Chem. 2007 May 15;15(10):3445-9. Epub 2007 Mar 12.Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens. | ||||
| Ref 528742 | Bioorg Med Chem. 2007 May 15;15(10):3445-9. Epub 2007 Mar 12.Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens. | ||||
| Ref 530988 | Bioorg Med Chem. 2010 Jun 15;18(12):4422-32. Epub 2010 Apr 29.ortho-Substituted C-aryl glucosides as highly potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors. | ||||
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