Target Validation Information
Target ID T55922
Target Name S-adenosylmethioninedecarboxylase proenzyme
Target Type
Clinical Trial
Drug Potency against Target 5'-Deoxy-5'-dimethylsulfonioadenosine chloride Drug Info IC50 = 5000 nM [529959]
5'-Deoxy-5'-(N,N-dimethylamino)adenosine Drug Info IC50 = 9000 nM [529959]
5'-Deoxy-5'-(N,N-dimethylamino)-8-methyladenosine Drug Info IC50 = 600 nM [529959]
[(2-aminooxyethyl)methylamino]-5'-deoxyadenosine Drug Info IC50 = 55 nM [529959]
References
Ref 529959J Med Chem. 2009 Mar 12;52(5):1388-407.New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C8 substitution in structural analogues of S-adenosylmethionine.
Ref 529959J Med Chem. 2009 Mar 12;52(5):1388-407.New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C8 substitution in structural analogues of S-adenosylmethionine.
Ref 529959J Med Chem. 2009 Mar 12;52(5):1388-407.New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C8 substitution in structural analogues of S-adenosylmethionine.
Ref 529959J Med Chem. 2009 Mar 12;52(5):1388-407.New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C8 substitution in structural analogues of S-adenosylmethionine.

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