| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T10513 | ||||
| Target Name | Integrin beta-2 | ||||
| Target Type | Discontinued |
||||
| Drug Potency against Target | A-286982 | Drug Info | IC50 = 44 nM | [526034] | |
| BMS-587101 | Drug Info | IC50 = 20 nM | [528539] | ||
| References | |||||
| Ref 526034 | J Med Chem. 2001 Apr 12;44(8):1202-10.Novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 2. Mechanism of inhibition and structure-based improvement of pharmaceutical properties. | ||||
| Ref 528539 | J Med Chem. 2006 Nov 30;49(24):6946-9.Discovery and development of 5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-yl-methyl]-3-thiophenecarboxylic acid (BMS-587101)--a small molecule antagonist of leukocyte function associated antigen-1. | ||||
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