Target Validation Information
Target ID T54644
Target Name Voltage-dependent T-type calcium channel subunit alpha-1H
Target Type
Successful
Drug Potency against Target U-92032 Drug Info IC50 = 300 nM [525864]
References
Ref 525864J Med Chem. 2000 Sep 7;43(18):3372-6.Discovery of (2S)-1-(4-amino-2,3,5- trimethylphenoxy)-3-[4-[4-(4- fluorobenzyl)phenyl]-1-piperazinyl]-2-propanol dimethanesulfonate (SUN N8075): a dual Na(+) and Ca(2+) channel blocker with antioxidant activity.

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